By administering Adequan Canine twice weekly for up to 4 weeks (maximum of 8 injections), the drug levels are sustained in the synovial joints for an extended period of time—giving the active ingredients time in the joint to help slow the progression of arthritis. The specific mechanism of action of Adequan® in canine joints is not known.

This subsequent series of injections are called "maintenance" because they help protect your dog’s joint health after the initial series of injections with Adequan Canine. If your dog is stiff, limping or has other symptoms of arthritis again, your veterinarian will likely repeat the dosing regimen to help get your dog back on track.

Adequan® Canine should not be used in dogs who are hypersensitive to polysulfated glycosaminoglycan (PSGAG) or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Adverse reactions in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/ lethargy and diarrhea have also been reported. The safe use of PSGAG in breeding, pregnant or lactating dogs has not been evaluated. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For additional safety information, please see the Full Prescribing Information.