Keep your dog moving for a lifetime of adventures

Arthritis is a progressive disease that gets worse as your dog gets older. Early treatment with Adequan® Canine (polysulfated glycosaminoglycan) can help prevent damage to the cartilage in your dog’s joints and preserve your dog’s activity level for years to come.1

Ask your veterinarian if Adequan Canine is right for your dog. Take our short quiz to help with your discussion.


The difference between feeling better and getting better®

Pain management can help your dog feel better, but it doesn’t prevent the cartilage in your dog’s joints from wearing away over time.

Adequan Canine is the only FDA-approved cartilage-protecting treatment that helps your dog get better by actually treating the disease, not just its symptoms.

Here’s how Adequan Canine is different from NSAIDs and joint supplements:

Adequan Canine

It has been proven to restore joint lubrication, relieve inflammation, and renew the building blocks of healthy cartilage.2 The specific mechanism of action of Adequan® in canine joints is not known.2


Several NSAIDs are FDA-approved to help control joint pain and inflammation associated with arthritis, but none are approved to slow the progression of the disease.

Joint Supplements

While some joint supplements have been used to support joint health, none have been proven to reduce inflammation in dogs with arthritis.3


Adequan® Canine polysulfated glycosaminoglycan (PSGAG)

Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.

Adequan® Canine should not be used in dogs who are hypersensitive to PSGAG or who have a known or suspected bleeding disorder. It should be used with caution in dogs with renal or hepatic impairment. Adverse reactions in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/lethargy and diarrhea have also been reported. The safe use of PSGAG in breeding, pregnant or lactating dogs has not been evaluated. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For additional safety information, please see full prescribing information.

Help keep your dog’s mobility on track

If your veterinarian diagnoses your dog with arthritis, they may recommend starting treatment with Adequan Canine to help prevent further joint damage.1

Adequan Canine is given by injection twice a week for up to four weeks (maximum of 8 injections) at the approved dose. You may see your dog’s mobility improve within one month. 4

Be sure to tell your veterinarian if you notice your dog is limping, stiff or slowing down. Your veterinarian may prescribe Adequan Canine as needed throughout your dog’s life to help protect their joints.

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Advancing joint care for dogs & horses

For more than 30 years, veterinarians have relied on the American Regent Animal Health family of products to provide solutions that help support joint health in their patients. Our mission is to champion the long-term well-being and mobility of animals, from top athletes to family companions.

  1. Epstein M, Kirkby Shaw K. Osteoarthritis in Dogs and Cats: Novel Therapeutic Advances. NAVC Proceedings. 2016.
  2. Adequan® Canine (polysulfated glycosaminoglycan), Package Insert. American Regent, Inc.
  3. Dietary Supplement Products & Ingredients. Accessed 5/2023.
  4. Adequan®  Canine (polysulfated glycosaminoglycan) NADA 141-038 FOI Summary, 1997.